AMPLIFY is a public-private research platform designed to propel innovation and resource-efficient methods to increase food yields. Created by the College of Agriculture and Life Sciences of N.C. State University, AMPLIFY was conceived as a transdisciplinary, entrepreneurial platform providing infrastructure for mobilizing research capability and intellectual capacity to solve complex global issues in agriculture. Advances in telemetry, remote sensing, and digital imaging, and precision machine guidance systems are generating multi-dimensional information that could drive agricultural decision-making at ground level and beyond if we know how to harness it. By pulling together basic and applied expertise from N.C. State’s College of Agriculture and Life Sciences, College of Sciences, and College of Engineering, AMPLIFY seeks to: (1) model photosynthesis, carbon metabolism, and partitioning, and water use efficiency (2) develop custom hyperspectral imaging systems for a seamless, integrated high-throughput phenomics pipeline; (3) fuse remote sensing information to quantify crop phenology, stress indicators, and soil-plant nutrient and water status; (4) model and identify high performance, resilient yield traits and create improved management strategies and decision support tools.